NTI Funded Studies Highlights
NTI has funded a total of 16 studies taking place at institutions in 20 states. We highlight two of them below: To learn more about all our studies, visit the Research page on the NTI website.
Multicenter Prospective Evaluation of the Ventilator Bundle in Injured Patients
Martin Croce, MD -- UT Memphis
Dr. Croce's multicenter study has two specific aims: 1) to determine the impact of the "ventilator bundle" on the incidence of ventilator-associated pneumonia (VAP) after injury, and 2) to ascertain the effect of the diagnostic criteria used for VAP on the incidence of VAP after injury.
The study is motivated by the lack of evidence to support usage of the ventilator bundle, which includes head of bed elevation, peptic ulcer prophylaxis, venous thrombosis prophylaxis, and sedation vacation with ventilator weaning. Multivariable analysis will allow for evaluation of bundle efficacy, and study of each bundle component.
In addition to UT Memphis, the other sites taking part in this study are UC San Diego, Wake Forest, MCW, Brown U, and Lehigh Valley. Dr. Croce and the participating sites are currently enrolling. Read More.
Characterization of the Effects of Early Sex-Hormone Environment Following Injury
Jason L. Sperry, MD, MPH -- U of Pittsburgh
Given that males and females respond differently following traumatic injury and hemorrhagic shock, the goal of Dr. Sperry's study is to further characterize and investigate the early sex-hormone environment following injury and the associations of early estrogen and testosterone levels with the strength of the innate immune response, the coagulation response, resuscitation requirements and clinical outcomes following injury.
The ultimate elucidation of the mechanisms responsible for outcome differences will allow future risk factors and therapeutic targets to be discovered and characterized, having significant potential to improve outcomes in both males and females following injury.
To date, Sperry's team has enrolled just under 200 patients, obtaining estradiol and testosterone samples in the first six hours post- injury. Early TEG analysis has also been obtained for each patient and multiple organ failure scores, nosocomial infection, and mortality have been prospectively been recorded. The team is beginning batched sex hormone measurements with patient accrual continuing. Read More. |
